AOD Thesaurus.  Annotated Hierarchy.  biomedicine.  EF - EG16.2
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EFeroute of administration   d-out   qh
SN The way in which a substance reaches its site of action in the body. The substance may be administered for therapeutic or psychoactive effects--possibly as part of a human or animal experiment--by a third party or by the subjects themselves, or the subject may be exposed to the substance through the environment or in utero.
      The major distinction between routes of administration is not the site where a substance is introduced or applied to the body, or even the way it is introduced or applied, but whether it takes effect merely in the local area where it is applied or whether it reaches its destination through systemic circulation. A further criterion is whether the drug reaches systemic circulation directly or whether it first passes through the liver, where it may be metabolized or excreted (first-pass effect in enteral administration). (Note: Drugs administered into the systemic circulation by any route, excluding intra-arterial injection, are subject to possible first-pass elimination in the lung prior to distribution to the rest of the body.)
      Whether administration of a drug results in local or systemic action depends not only on the site and method of administration but also on the properties of the drug; sometimes the drug has both local and systemic action. This is particularly true for application to a mucous membrane, which may be intended for a local action but also may include, sometimes unwanted, systemic action. Furthermore, a drug may be absorbed at several sites (e.g., the mouth and the lung, the rectum and the intestine) in various proportions. To account at least partially for the very complex phenomena of the absorption of drugs into the body, the following classification uses two dimensions, or facets: by scope of drug action and by method or body site of administration. To index the route of administration completely, use at least one descriptor from each facet.
      Combine with *+EE20 chemical exposure* qh ah to indicate accidental or inadvertent contact with a substance.
ST medication route
method of delivery of drugs or food
mode of substance administration
route of drug application
route of drug entry
route of exposure
BT+EE12e pharmacokinetics    qh   ah
RT+AA2e AOD use    qh   ah
+BS AOD substance by route of administration    qh   ah
 EE12.2e drug absorption    qh   ah
+EE14.4.8 drug effect by location    qh   ah
+EE20e chemical exposure    qh   ah
+HK2.10.2.2.4 nicotine replacement    qh   ah
+HRe drug therapy    qh   ah
 OC2 drug paraphernalia    qh   ah

EF2route of administration by scope of drug action   qh
HN Introduced 1995.
SN Use at least one of the narrower descriptors and combine it with the appropriate descriptor from *+EF4 route of administration by method or body site* qh ah. If specific information is not available, use this broad descriptor.
EF2.2.  topical and local administration   qh
HN Introduced 1995.
SN The application of a substance to a localized area, chiefly for local effects at this site.
NT HU4.2 local anesthesia    qh   ah
RT EE14.4.8.2 local drug effect    qh   ah
 GH10.2 chemical injury    qh   ah
EF2.2.2.  .  topical administration   qh
SN The application of a substance on the surface of the skin or on a mucous membrane (including the gastrointestinal membrane) so that the substance will take effect on the surface or on a localized layer under the surface. For example, for the administration of a decongestant spray, use *EF2.2.2 topical administration* qh ah combined with *EF4.4.4.4 nasal administration* qh ah.
ST topical application
EF2.2.4.  .  local drug administration   qh
HN Introduced 1995.
SN The introduction of a substance into a localized area of the skin or other tissue, for example, through injection.
NT EF4.6.4 intra-arterial injection    qh   ah
 EF4.6.8 intracutaneous injection    qh   ah
+EF4.6.16 CNS injection    qh   ah
EF2.4.  systemic administration   qh
HN Introduced 1995.
SN The introduction of a substance into systemic circulation so that it is carried to the site of effect.
NT+EF4.6.2e intravenous injection    qh   ah
 EF4.6.10 administration through skin implant    qh   ah
 HU4.4 general anesthesia    qh   ah
RT EE14.4.8.4 systemic drug effect    qh   ah
+EF4.4.4 inhalation, smoking, sniffing    qh   ah
+GH10.4 chemical poisoning    qh   ah

EF4route of administration by method or body site   qh
HN Introduced 1995.
SN Because in many cases a drug can have local or systemic effects regardless of the method or body site of administration, any of these descriptors should be combined with the appropriate descriptor from *+EF2 route of administration by scope of drug action* qh ah. Where appropriate, a route of administration can be specified further by combining it with a descriptor from *+X body part* qh ah, for example, *EF4.6.14 intramuscular injection* qh ah combined with *+XD8.4 leg* qh ah.
      The classification given here, especially the grouping of a number of routes under the heading *+EF4.4 mucosal administration* qh ah, follows, in part, Taber's Cyclopedic Medical Dictionary, 17th ed., 1993. Both *+EF4.2 enteral administration* qh ah and *+EF4.4 mucosal administration* qh ah leave body membranes intact, whereas *+EF4.6 parenteral administration* qh ah introduces substances into the body by mechanically penetrating a membrane.
RT+EF2 route of administration by scope of drug action    qh   ah
EF4.2e.  enteral administration   qh
SN The administration of a substance by way of the gastrointestinal tract (i.e., stomach and intestine), usually for systemic action. A drug that is absorbed from the stomach or intestine first must pass through the liver; therefore, some of the active drug will be inactivated or diverted before it can reach systemic circulation.
ST nonparenteral administration
EF4.2.2.  .  oral enteral administration   qh
HN Introduced 1995.
SN The introduction of a substance into the gastrointestinal tract by way of the mouth, usually for systemic action. The drug will be exposed to the gastric environment, which transforms some drugs. For administration by way of absorption through the oral mucosa, use *+EF4.4.6 oral mucosal administration* qh ah or a narrower term. The term "oral administration," or simply "orally," often is used in the narrower meaning of "oral enteral administration" as defined here.
ST drug ingestion
per os administration
PO administration
BT+EF4.10e oral administration    qh   ah
RT+EA24.8e nutrient intake    qh   ah
EF4.2.4.  .  rectal enteral administration   qh
HN Introduced 1995.
SN The introduction of a substance into the gastrointestinal tract by way of the rectum, usually for systemic action. For application by way of absorption through the rectal mucosa, use *EF4.4.8 rectal mucosal administration* qh ah. If both ways of absorption apply or if in doubt, use the broader term *+EF4.12 rectal administration* qh ah.
BT+EF4.12 rectal administration    qh   ah
EF4.4e.  mucosal administration   qh
HN ETOH descriptor 2000.
SN The administration of a substance by way of application to a mucous membrane (other than the gastrointestinal tract), the pulmonary epithelium, or the skin. The drug action may be topical/local, systemic (through absorption by a mucous membrane or other surface), or a combination of both. The classification is based primarily on the site where the absorption takes place, not on the site where the substance enters the body. Thus, in pulmonary administration, the gas could be inhaled through the mouth or through the nose. Unless implied by the specific narrower descriptor, combine with the appropriate descriptor from *+X body part* qh ah to indicate the site of the application.
RT EF4.6.6e intraperitoneal administration    qh   ah
 XQ4.2.18 vagina    qh   ah
+XV6.2e eye    qh   ah
EF4.4.2e.  .  transdermal administration   qh
HN Introduced 1995. ETOH descriptor 2000.
SN Administration of a substance by way of absorption through the skin, usually for systemic action.
ST cutaneous application
BT+EF4.8 skin administration    qh   ah
+XH2e skin    qh   ah
RT EF4.6.10 administration through skin implant    qh   ah
 EF4.6.12 subcutaneous injection    qh   ah
EF4.4.2.2.  .  .  skin patch   qh
RT+BDe tobacco in any form    qh   ah
EF4.4.2.4e.  .  .  iontophoresis   qh
HN Introduced 2000.
SN Therapeutic introduction of ions of soluble salts into tissues by means of electric current. Iontophoresis can be used for local and systemic drug delivery without the complications of injection. In medical literature it is commonly used to indicate the process of increasing the penetration of drugs into surface tissues by the application of electric current. (It has nothing to do with ion exchange, air ionization nor phonophoresis, none of which requires current.)
ST galvanoionization
iontotherapy
medical ionization
BT+CQ12.22.6e electrophoresis    qh   ah
+HP8.12 electrotherapy    qh   ah
EF4.4.2.4.2e.  .  .  .  microiontopheresis   qh
HN Introduced 2000.
EF4.4.4.  .  inhalation, smoking, sniffing   qh
HN Introduced 1995.
SN The administration of a substance in the form of a gas, aerosol (including smoke), or fine powder by way of the nose, lung, or mouth.
      Use this descriptor only if specific information is not available; otherwise, use all applicable narrower descriptors. Examples: If a drug is inhaled through the mouth or the nose but is absorbed mostly in the lung, use *+EF4.4.4.6 pulmonary administration* qh ah; if a drug is inhaled through the nose and is absorbed in significant proportions in both the nose and the lung, use both *EF4.4.4.4 nasal administration* qh ah and *+EF4.4.4.6 pulmonary administration* qh ah.
ST insufflation
RT+BGe volatile inhalant    qh   ah
+EF2.4 systemic administration    qh   ah
EF4.4.4.2e.  .  .  smoking   qh
HN ETOH descriptor 1995.
SN "Smoking" often is used to mean "smoking tobacco." However, here the descriptor smoking refers to smoking any substance. To index tobacco smoking, combine with *+BD tobacco in any form* qh ah or the appropriate narrower descriptor.
NT OD2.4 freebasing    qh   ah
BT+EF4.10e oral administration    qh   ah
RT+BDe tobacco in any form    qh   ah
+BD6 tobacco smoke    qh   ah
+BEe marijuana in any form    qh   ah
+BS4e inhaled substance    qh   ah
+EE20.2 passive inhalation    qh   ah
EF4.4.4.2.2.  .  .  .  smoking without inhalation   qh
HN Introduced 1995.
EF4.4.4.2.4.  .  .  .  smoking with inhalation   qh
HN Introduced 1995.
BT+EF4.4.4.6e pulmonary administration    qh   ah
EF4.4.4.4e.  .  .  nasal administration   qh
HN ETOH descriptor 2000.
SN The administration of a substance by way of the nose, often with systemic action due to absorption through the nasal mucosa.
ST drug blowing
drug sniffing
drug snorting
BT+XK2.2.2 nasal membrane    qh   ah
RT BK4.4 cocaine powder    qh   ah
+BS4e inhaled substance    qh   ah
 EF2.2.2 topical administration    qh   ah
 XK2.4e pharynx    qh   ah
EF4.4.4.6e.  .  .  pulmonary administration   qh
HN ETOH descriptor 2000.
SN The administration of a substance in the form of a gas or aerosol through inhalation into the lung, often with systemic action due to absorption through the pulmonary epithelium and mucous membranes of the respiratory tract.
ST drug inhalation (nose)
huffing
NT EF4.4.4.2.4 smoking with inhalation    qh   ah
BT+XK4e lung    qh   ah
EF4.4.4.6.2.  .  .  .  nicotine inhaler   qh
HN Introduced 2000.
BT+BDe tobacco in any form    qh   ah
+HK2.10.2.2.4 nicotine replacement    qh   ah
EF4.4.4.6.4.  .  .  .  nicotine spray   qh
HN Introduced 2000.
BT+BDe tobacco in any form    qh   ah
EF4.4.6.  .  oral mucosal administration   qh
HN Introduced 1995.
SN The administration of a substance to the oral mucosa, often with systemic action due to absorption.
NT EN2 chewing    qh   ah
BT+EF4.10e oral administration    qh   ah
RT BD4.6.2 chewing tobacco    qh   ah
 BJ4.4.4e betel nut    qh   ah
 EF4.2.2 oral enteral administration    qh   ah
EF4.4.6.2.  .  .  buccal administration   qh
HN Introduced 1995.
SN The administration of a substance to the mucosa on the inside of the cheek or the back of the mouth.
EF4.4.6.4.  .  .  sublingual administration   qh
SN The administration of a substance to the mucosa of the tongue and under the tongue.
BT+XL2.4 tongue    qh   ah
RT BD4.6.2 chewing tobacco    qh   ah
 BJ4.4.4e betel nut    qh   ah
EF4.4.8.  .  rectal mucosal administration   qh
HN Introduced 1995.
BT+EF4.12 rectal administration    qh   ah
RT EF4.2.4 rectal enteral administration    qh   ah
EF4.6e.  parenteral administration   qh
SN The administration of a substance through injection or infusion. Usually the drug action is systemic, but in some cases, it is confined to a local area. Combine with the appropriate descriptor from *+X body part* qh ah to indicate the site of the injection.
ST infusion
injection
NT+EE20.6e prenatal chemical exposure    qh   ah
RT BS2e injected substance    qh   ah
EF4.6.2e.  .  intravenous injection   qh
HN ETOH descriptor 1995.
ST IV injection
mainlining
shooting up
BT+EF2.4 systemic administration    qh   ah
+XJ6.4e vein    qh   ah
RT+BS AOD substance by route of administration    qh   ah
 BS2e injected substance    qh   ah
 TL4.10.4e intravenous drug user    qh   ah
EF4.6.2.2.  .  .  intravenous infusion   qh
EF4.6.4.  .  intra-arterial injection   qh
SN Occasionally a drug is injected directly into an artery to localize its effect to a particular tissue or organ. However, this practice usually has dubious therapeutic value. Diagnostic agents sometimes are administered by this route. Intra-arterial injection requires great care and should be reserved for experts. The first-pass and cleansing effects of the lung are not available when drugs are given by this route.
BT+EF2.2.4 local drug administration    qh   ah
+XJ6.2e artery    qh   ah
EF4.6.6e.  .  intraperitoneal administration   qh
HN ETOH descriptor 1995.
SN Injection of a substance into the peritoneum, where it is absorbed by the lining. The substance is subject to first pass through the liver.
ST intraperitoneal infusion
intraperitoneal injection
BT+XD6.4.4e peritoneum    qh   ah
RT+EF4.4e mucosal administration    qh   ah
EF4.6.8.  .  intracutaneous injection   qh
HN Introduced 1995.
ST endermic injection
intradermal injection
BT+EF2.2.4 local drug administration    qh   ah
+EF4.8 skin administration    qh   ah
+XH2e skin    qh   ah
EF4.6.10.  .  administration through skin implant   qh
HN Introduced 1995.
BT+EF2.4 systemic administration    qh   ah
+EF4.8 skin administration    qh   ah
+XH2e skin    qh   ah
RT+EF4.4.2e transdermal administration    qh   ah
EF4.6.12.  .  subcutaneous injection   qh
ST hypodermic injection
skin popping
subcutaneous application
BT+EF4.8 skin administration    qh   ah
+XH2e skin    qh   ah
RT+EF4.4.2e transdermal administration    qh   ah
EF4.6.14.  .  intramuscular injection   qh
ST IM injection
RT+EF4 route of administration by method or body site    qh   ah
EF4.6.16.  .  CNS injection   qh
HN Introduced 1995.
BT+EF2.2.4 local drug administration    qh   ah
+XZe central nervous system    qh   ah
EF4.6.16.2.  .  .  intrathecal injection   qh
SN Injection of drugs directly into the spinal subarachnoid space in order to achieve local, rapid effects on the meninges or cerebrospinal axis. Used in spinal anesthesia or acute CNS infections in order to bypass the *XZ2.2.4 blood-brain barrier* qh ah.
EF4.8.  skin administration   qh
NT+EF4.4.2e transdermal administration    qh   ah
 EF4.6.8 intracutaneous injection    qh   ah
 EF4.6.10 administration through skin implant    qh   ah
 EF4.6.12 subcutaneous injection    qh   ah
BT+XH2e skin    qh   ah
RT HF20.22 skin test    qh   ah
EF4.10e.  oral administration   qh
HN ETOH descriptor 1995.
NT EF4.2.2 oral enteral administration    qh   ah
+EF4.4.4.2e smoking    qh   ah
+EF4.4.6 oral mucosal administration    qh   ah
BT+XL2e mouth    qh   ah
EF4.12.  rectal administration   qh
SN With rectal administration that is not purely topical, some proportion of the drug may be absorbed directly through the rectal mucosa and not be subject to first pass through the liver, whereas another portion may pass into the intestine and be absorbed from there.
NT EF4.2.4 rectal enteral administration    qh   ah
 EF4.4.8 rectal mucosal administration    qh   ah
BT+XM2.4.10e rectum    qh   ah

EF6drug administration by self versus others   qh
HN Introduced 1995.
SN This aspect often is not indexed, except for *EF6.2 self-administration of drugs* qh ah by animals in animal studies or self use of a method of administration normally performed by others, such as injection.
EF6.2e.  self-administration of drugs   qh
EF6.4.  drug administration by others   qh
HN Introduced 1995.


EGecell function   d-out   qh
BT+EAe general life processes    qh   ah
+XAe cell and cell structure    qh   ah

EG2ecell growth and differentiation   qh
ST cell development
BT+EDe growth and development    qh   ah
RT+ED4.10.2.4 organogenesis    qh   ah
 ED6.4.4 biological involution    qh   ah
 ET4.6.4 lymphocyte activation    qh   ah
EG2.2.  cell division   qh
ST cell growth
cell proliferation
cell replication
EG2.2.2.  .  cell cycle   qh
RT+ED6e biological life cycle    qh   ah
EG2.2.4.  .  mitosis   qh
RT+XA2.2e cell nucleus    qh   ah
EG2.2.6.  .  meiosis   qh
RT+ES4.2 gametogenesis    qh   ah
+XA2.2e cell nucleus    qh   ah
EG2.4.  cell differentiation   qh
SN A process by which cells become specialized in structure and function
EG2.6.  cell life cycle   qh
HN Introduced 2000.
EG2.6.6e.  .  cytolysis   qh
HN ETOH descriptor 1995.
SN Destruction or breakdown of the living cell, primarily by disintegration of the outer membrane.
ST cell death
NT+GG14.6e necrosis    qh   ah
RT ED6.6 biological death    qh   ah
+ET4e immune function    qh   ah
EG2.6.6.2e.  .  .  apoptosis   qh
HN Introduced 2000.
SN A series of chemical reactions within a cell that are induced by various events and which result in the cell's death.
EG2.8e.  cell migration   qh
HN ETOH descriptor 2000.
SN The movement of maturing cells to their ultimate locations so that they can serve a specific role in the overall coordinated activity of an organ.
ST cellular migration
BT+ED4.4.2 morphogenesis    qh   ah
RT+ED4.10.2.4 organogenesis    qh   ah
 ET4.6.4 lymphocyte activation    qh   ah
EG2.8.2e.  .  chemotaxis   qh
HN ETOH descriptor 2000.
ST chemiotaxis
chemotropism
RT+EA14 biological movement    qh   ah
+XS2.10e leukocytes    qh   ah

EG6cell-cell interaction   qh
RT+ED4.4.2 morphogenesis    qh   ah
+EG10e cell signaling    qh   ah
EG6.6.  cell aggregation   qh
BT+ED4.4.2 morphogenesis    qh   ah
RT ET2.4.2.2e platelet aggregation    qh   ah

EG8ecell electrophysiology   qh
SN Use this descriptor for general mention; more specific descriptors appear under *+EG10 cell signaling* qh ah, *EG12 signal transduction* qh ah, *+EG14 cell membrane biology* qh ah, and *+EG16 mitochondrial biology* qh ah.
NT+HG22.8.6e evoked potential    qh   ah
BT+EA2e electrical life processes    qh   ah
RT+CB26 electrical property    qh   ah
 EG14.8.4.4e voltage gated channel    qh   ah
 EW6.4 electrical neurotransmission    qh   ah
+HE8e electrodiagnosis    qh   ah

EG10ecell signaling   qh
NT+EW6e neurotransmission    qh   ah
RT+EG6 cell-cell interaction    qh   ah
+EG8e cell electrophysiology    qh   ah
 EG14.2e receptor ligand binding    qh   ah
+YFe hormones    qh   ah
+YKe receptors    qh   ah
EG10.2.  electrical cell signaling   qh
HN Introduced 1995.
NT EW6.4 electrical neurotransmission    qh   ah
RT EG14.8.4.4e voltage gated channel    qh   ah
EG10.4.  chemical cell signaling   qh
HN Introduced 1995.
NT EW6.6 chemical neurotransmission    qh   ah
RT+YFe hormones    qh   ah
+YKe receptors    qh   ah

EG12esignal transduction   qh
ST sensory transduction
BT+EV2e sensation    qh   ah
RT+EG8e cell electrophysiology    qh   ah
+EVe sensory system function    qh   ah

EG14cell membrane biology   qh
RT+EC2e biological transport    qh   ah
+EG8e cell electrophysiology    qh   ah
+XA2.12e cell membrane    qh   ah
+YKe receptors    qh   ah
EG14.2e.  receptor ligand binding   qh
SN Please note that documents will often discuss the concept of receptor binding without explicitly mentioning ligands. Receptor binding always involves ligands.
ST receptor binding
receptor coupling
receptor ligand affinity
RT CK2.4e structure activity relationship    qh   ah
+EE12.4.4e drug binding    qh   ah
+EG10e cell signaling    qh   ah
+YKe receptors    qh   ah
EG14.4e.  membrane fluidity   qh
EG14.6e.  membrane permeability   qh
ST membrane gating properties
RT+EC2.6e passive transport    qh   ah
EG14.8e.  membrane channel   qh
SN Proteins that span the cell membrane, forming pores that regulate the flow of specific charged particles into and out of the cell. Use to index documents dealing with membrane structures involved in transmembrane transport.
      Use *+EC2 biological transport* qh ah or narrower terms to index documents containing less specific concepts.
ST ion channels
NT ZO6.4.6.4e membrane transport protein    qh   ah
BT+XA2.12e cell membrane    qh   ah
RT+EC2e biological transport    qh   ah
 EC2.10e ion transport    qh   ah
 YD8.12.2e ionophores    qh   ah
+YKe receptors    qh   ah
+YK6.4.4e nicotinic receptor    qh   ah
EG14.8.2.  .  nongated membrane channel   qh
ST nongated ion channel
RT+EC2.6e passive transport    qh   ah
EG14.8.4.  .  gated membrane channel   qh
ST gated ion channel
EG14.8.4.2.  .  .  receptor operated channel   qh
ST chemically gated channels
ligand gated ion channels
ROC
RT+YKe receptors    qh   ah
EG14.8.4.4e.  .  .  voltage gated channel   qh
HN ETOH descriptor 1995.
ST voltage activated ion channel
voltage gated ion channel
RT+EG8e cell electrophysiology    qh   ah
+EG10.2 electrical cell signaling    qh   ah
EG14.8.6e.  .  chloride channel   qh
RT+YK6.8e GABA receptors    qh   ah
 YK10e benzodiazepine receptors    qh   ah
EG14.8.8e.  .  calcium channel   qh
RT YK6.10.2e NMDA receptors    qh   ah
EG14.8.10e.  .  potassium channel   qh
HN Introduced 2000.
SN Potassium channels play a major role in regulating membrane potential and producing membrane repolarization following transmission of nerve impulses.
EG14.8.12.  .  antiport   qh
EG14.10.  endocytosis or exocytosis   qh
EG14.10.2e.  .  endocytosis   qh
EG14.10.2.2e.  .  .  phagocytosis   qh
HN ETOH descriptor 1995.
ST autophagy/autophagia
BT+ET4.6.6 antigen elimination    qh   ah
RT XA2.4.10e lysosome    qh   ah
 XS2.10.2.2e neutrophilic granulocyte    qh   ah
EG14.10.2.4.  .  .  pinocytosis   qh
EG14.10.4e.  .  exocytosis   qh

EG16mitochondrial biology   qh
RT+EG8e cell electrophysiology    qh   ah
 XA2.4.8e mitochondria    qh   ah
EG16.2e.  mitochondrial transport   qh
NT+EB4.4e electron transfer    qh   ah
BT+EC2e biological transport    qh   ah
RT+ZA2.4.4.6e calcium    qh   ah


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